Yu Hongsheng, Zhang Lei, Li Lin, Li Wenchao, Han Ting, Guo Liangdong, Qin Luping
Department of Pharmacognosy, School of Phannrmacy, Second Military Medical University, Shanghai 200433, China.
Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(16):2133-7.
To research the isolation method, identification and screen for bioactivities endophytic fungi from ginkgo.
Endophytic fungi from ginkgo were separated. By means of microdilution method, activities of endophytes against pathogenic fungi were tested. Then, using DPPH, the antioxidant activities were measured.
Nine strains (16.1%) showed antifungal activities against Candida albicans, Cryptococcus neoformans, Trichophyton rubrum and Aspergillus fumigatus. Among these bioactive strains, the growth of T. rubrum was strongly inhibited by T-1-2-1, as the MIC80 was equal to fluconazole, the positive control. Five strains (8.9%) showed antioxidant activities. Among them sample T-3-2-2 and T-6-5-7 showed the strongest antioxidant activities.
Endophytic fungi of ginkgo would be potential and rich resources for drug development.
