Chatterjee Manavi, Verma Pinki, Palit Gautam
Division of Pharmacology, Central Drug Research Institute, CSIR, Lucknow 226 001, India.
Indian J Exp Biol. 2010 Mar;48(3):306-13.
The present study was undertaken to compare medicinal plants against mixed anxiety-depressive disorder (MAD) to evaluate their potency in combating MAD disorders. Previous studies from our lab have shown that Bacopa monniera (BM), and Panax quniquefolium (PQ) have significant adaptogenic properties. Hence, we have further confirmed their activity in stress related disorders like anxiety and depression in animal model, rodents and assessed their efficacy. In our experimental protocol, gross behaviour was observed through Digiscan animal activity monitor. Anxiety was studied through light dark test, elevated plus maze test and holeboard test. Depression experiments were conducted following tail suspension test and forced swim test. Further, rotarod test was also used to study any defects in motor in-coordination in mice. It was observed that BM at the dose of 80 mg/kg (po) and PQ at 100 mg/kg (po) were effective as an anti-anxiety as well anti-depressant activity and had no motor in-coordination in mice. Hence, these extracts can be used as a potent therapeutic agent in treating mixed anxiety-depressive disorder (MAD).
本研究旨在比较药用植物对混合性焦虑抑郁障碍（MAD）的作用，以评估它们对抗MAD疾病的效力。我们实验室之前的研究表明，水龙骨（BM）和西洋参（PQ）具有显著的适应原特性。因此，我们进一步在动物模型（啮齿动物）中证实了它们在焦虑和抑郁等应激相关疾病中的活性，并评估了它们的疗效。在我们的实验方案中，通过Digiscan动物活动监测仪观察总体行为。通过明暗试验、高架十字迷宫试验和洞板试验研究焦虑情况。按照悬尾试验和强迫游泳试验进行抑郁实验。此外，还使用转棒试验研究小鼠运动不协调方面的任何缺陷。观察到剂量为80mg/kg（口服）的BM和100mg/kg（口服）的PQ具有抗焦虑和抗抑郁活性，且小鼠无运动不协调现象。因此，这些提取物可作为治疗混合性焦虑抑郁障碍（MAD）的有效治疗剂。
