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细菌细胞骨架。

The bacterial cytoskeleton.

机构信息

Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.

出版信息

Annu Rev Genet. 2010;44:365-92. doi: 10.1146/annurev-genet-102108-134845.

Abstract

Bacteria, like eukaryotes, employ cytoskeletal elements to perform many functions, including cell morphogenesis, cell division, DNA partitioning, and cell motility. They not only possess counterparts of eukaryotic actin, tubulin, and intermediate filament proteins, but they also have cytoskeletal elements of their own. Unlike the rigid sequence and structural conservation often observed for eukaryotic cytoskeletal proteins, the bacterial counterparts can display considerable diversity in sequence and function across species. Their wide range of function highlights the flexibility of core cytoskeletal protein motifs, such that one type of cytoskeletal element can perform various functions, and one function can be performed by different types of cytoskeletal elements.

摘要

细菌与真核生物一样,利用细胞骨架元件来执行许多功能,包括细胞形态发生、细胞分裂、DNA 分配和细胞运动。它们不仅拥有真核生物肌动蛋白、微管蛋白和中间丝蛋白的对应物,而且还具有自己的细胞骨架元件。与真核细胞骨架蛋白通常观察到的刚性序列和结构保守性不同,细菌对应物在物种间的序列和功能上可以显示出相当大的多样性。它们广泛的功能突出了核心细胞骨架蛋白基序的灵活性,使得一种类型的细胞骨架元件可以执行各种功能,并且一种功能可以由不同类型的细胞骨架元件来执行。

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