Vélez Marisela
Instituto de Catálisis y Petroleoquímica, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Front Microbiol. 2022 May 3;13:757711. doi: 10.3389/fmicb.2022.757711. eCollection 2022.
FtsZ is the cytoskeletal protein that organizes the formation of the septal ring and orchestrates bacterial cell division. Its association to the membrane is essential for its function. In this mini-review I will address the question of how this association can interfere with the structure and dynamic properties of the filaments and argue that its dynamics could also remodel the underlying lipid membrane through its activity. Thus, lipid rearrangement might need to be considered when trying to understand FtsZ's function. This new element could help understand how FtsZ assembly coordinates positioning and recruitment of the proteins forming the septal ring inside the cell with the activity of the machinery involved in peptidoglycan synthesis located in the periplasmic space.
FtsZ是一种细胞骨架蛋白，它组织隔膜环的形成并协调细菌细胞分裂。它与膜的结合对其功能至关重要。在这篇小型综述中，我将探讨这种结合如何干扰细丝的结构和动态特性，并认为其动态变化也可能通过其活性重塑底层脂质膜。因此，在试图理解FtsZ的功能时，可能需要考虑脂质重排。这一新因素有助于理解FtsZ组装如何将细胞内形成隔膜环的蛋白质的定位和募集与位于周质空间的肽聚糖合成相关机制的活性相协调。
