Department of Evolutionary Biology, University of Siena, Via A. Moro 2 53100 Siena, Italy.
Tissue Cell. 2010 Dec;42(6):339-47. doi: 10.1016/j.tice.2010.10.004. Epub 2010 Nov 2.
An essential step in many forms of cell death is the release from mitochondria of "death effectors" which once in the cytoplasm activate signalling pathways leading to cellular demise. In this context mitochondria are known as regulators of cell death functioning as a node where signals are integrated. The discovery that alterations and remodelling of ultrastructural architecture of mitochondria are required to trigger the complete release of cytochrome c in the cytoplasm and the notion that mitochondrial architecture determines/influences the function of this organelle has fostered investigations on mitochondrial dynamics and on the machinery that regulates this process during cell death. In this review I shall summarize the current knowledge of mitochondrial inner membrane remodelling during cell death and discuss the role of mitochondrial proteins in governing structural alterations. I shall then discuss the role of the adaptor protein p66Shc as a regulator of mitochondrial metabolism during apoptosis.
在许多形式的细胞死亡中，一个重要步骤是线粒体释放“死亡效应器”，这些效应器一旦进入细胞质，就会激活导致细胞死亡的信号通路。在这种情况下，线粒体被称为细胞死亡的调节剂，作为一个整合信号的节点。发现线粒体超微结构的改变和重塑是触发细胞质中细胞色素 c 完全释放所必需的，并且线粒体结构决定/影响这个细胞器的功能的观点促进了对线粒体动力学和调节细胞死亡过程中这个过程的机制的研究。在这篇综述中，我将总结细胞死亡过程中线粒体内膜重塑的最新知识，并讨论线粒体蛋白在调节结构改变中的作用。然后，我将讨论衔接蛋白 p66Shc 在细胞凋亡过程中作为线粒体代谢调节剂的作用。
