Unit of Infections and Cancer (UNIC), IDIBELL, Institut Català d’Oncologia, L’Hospitalet de Llobregat, Barcelona, Spain.
Haematologica. 2011 Feb;96(2):323-7. doi: 10.3324/haematol.2010.031161. Epub 2010 Nov 3.
Using EpiLymph case-control data, we found that chronic lymphocytic leukemia patients were more likely to have abnormal reactive serological patterns to Epstein Barr virus than controls. Here, we aimed to assess whether this association is modified by genetic variants. We examined 1,305 Single Nucleotide Polymorphisms from 300 selected genes related to various pathways in 240 cases and 513 controls from five European centers. In a recessive model, patients positive to aberrant antibody pattern and homozygous for rare genotypes in rs8113877T>G or rs17576A>G of the MMP9 gene were at highest risk of chronic lymphocytic leukemia. In a dominant model, TP73 showed the highest risk in patients positive to aberrant antibody pattern and homozygous for the wild-type genotype in rs1885859G>C or rs3765701A>T. All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted.
利用 EpiLymph 病例对照数据，我们发现慢性淋巴细胞白血病患者比对照组更有可能出现异常的反应性血清学模式来对抗 Epstein Barr 病毒。在这里，我们旨在评估这种关联是否被遗传变异所修饰。我们在五个欧洲中心的 240 例病例和 513 例对照中，检查了 300 个与各种途径相关的基因中的 1305 个单核苷酸多态性。在隐性模型中，MMP9 基因 rs8113877T>G 或 rs17576A>G 中罕见基因型纯合且抗体模式异常的患者患慢性淋巴细胞白血病的风险最高。在显性模型中，TP73 在 rs1885859G>C 或 rs3765701A>T 中野生型基因型纯合且抗体模式异常的患者中风险最高。所有的相互作用都是相加的，没有观察到主要作用。观察到的强烈相互作用可能表明癌症发生中的特定途径。需要证实这些结果。
