Department of Biochemistry, Faculty of Medicine, University of Gaziantep Gaziantep, Turkey.
Minerva Med. 2010 Oct;101(5):305-10.
Oxidative/nitrosative stress has long been demonstrated in hemodialysis patients. It is associated with numerous complications such as atherosclerosis and related cardiovascular disturbances. However, the factors influencing oxidative/nitrosative status have not been characterized extensively in these patients. Therefore, the present study was designed to investigate the alteration of oxidative/nitrosative stress parameters and total antioxidant status.
Forty-one hemodialysis patients and 41 healthy subjects were enrolled in the present study. Serum myeloperoxidase, nitrotyrosine and total antioxidant capacity were determined.
Serum myeloperoxidase and nitrotyrosine were significantly higher in the haemodialysis patients compared to the healthy subjects (P<0.05) while total antioxidant capacity was lower (P<0.01).
According to the results of this study, oxidative and nitrosative stress is increased in haemodialysis patients, therefore these alterations should be considered in the treatment of these patients.
氧化/硝化应激在血液透析患者中早已得到证实。它与许多并发症有关，如动脉粥样硬化和相关的心血管紊乱。然而，影响氧化/硝化状态的因素在这些患者中尚未得到广泛描述。因此，本研究旨在探讨氧化/硝化应激参数和总抗氧化状态的变化。
本研究纳入了 41 名血液透析患者和 41 名健康受试者。测定血清髓过氧化物酶、硝基酪氨酸和总抗氧化能力。
与健康受试者相比，血液透析患者的血清髓过氧化物酶和硝基酪氨酸明显升高（P<0.05），而总抗氧化能力降低（P<0.01）。
根据本研究的结果，血液透析患者的氧化和硝化应激增加，因此在治疗这些患者时应考虑这些改变。
