Department of Biochemistry, Faculty of Pharmacy, Ege University, Izmir, Turkey.
Blood Purif. 2011;32(3):202-8. doi: 10.1159/000328030. Epub 2011 Jul 29.
The aim of this study was to evaluate the effects of hemodialysis (HD) and peritoneal dialysis (PD) treatments on oxidative and nitrosative stress markers comparatively.
Twenty HD and 20 PD patients as well as 20 healthy individuals were included in this study. Plasma advanced oxidation protein products, myeloperoxidase, thiol group and 3-nitrotyrosine (3-NT) levels were measured in all subjects.
Plasma advanced oxidation protein products and myeloperoxidase levels were elevated by HD and PD treatments when compared to the control group. Conversely, plasma thiol group levels were decreased in HD and PD patients. 3-NT levels were increased by HD treatment only.
The elevated plasma 3-NT levels in pre-HD and post-HD patients suggest that those patients have a considerably increased risk for nitrosative tissue injury. However, similar 3-NT levels of the control and PD groups support the advantage of PD therapy in terms of nitrosative tissue injury.
本研究旨在比较血液透析（HD）和腹膜透析（PD）治疗对氧化和硝化应激标志物的影响。
本研究纳入了 20 名 HD 患者、20 名 PD 患者和 20 名健康个体。所有受试者的血浆晚期氧化蛋白产物、髓过氧化物酶、巯基基团和 3-硝基酪氨酸（3-NT）水平均被测量。
与对照组相比，HD 和 PD 治疗使血浆晚期氧化蛋白产物和髓过氧化物酶水平升高，而 HD 和 PD 患者的血浆巯基基团水平降低。仅 HD 治疗使 3-NT 水平升高。
在 HD 前和 HD 后患者的血浆 3-NT 水平升高表明这些患者的硝化组织损伤风险显著增加。然而，对照组和 PD 组的相似 3-NT 水平支持 PD 治疗在硝化组织损伤方面的优势。
