Department of Neurosurgery, University Hospital Antwerp, Brai2n, Tinnitus Research Institute, Edegem, Belgium.
PLoS One. 2010 Oct 27;5(10):e13618. doi: 10.1371/journal.pone.0013618.
Tinnitus is an auditory sensation characterized by the perception of sound or noise in the absence of any external sound source. Based on neurobiological research, it is generally accepted that most forms of tinnitus are attributable to maladaptive plasticity due to damage to auditory system. Changes have been observed in auditory structures such as the inferior colliculus, the thalamus and the auditory cortex as well as in non-auditory brain areas. However, the observed changes show great variability, hence lacking a conclusive picture. One of the reasons might be the selection of inhomogeneous groups in data analysis.
The aim of the present study was to delineate the differences between the neural networks involved in narrow band noise and pure tone tinnitus conducting LORETA based source analysis of resting state EEG.
Results demonstrated that narrow band noise tinnitus patients differ from pure tone tinnitus patients in the lateral frontopolar (BA 10), PCC and the parahippocampal area for delta, beta and gamma frequency bands, respectively. The parahippocampal-PCC current density differences might be load dependent, as noise-like tinnitus constitutes multiple frequencies in contrast to pure tone tinnitus. The lateral frontopolar differences might be related to pitch specific memory retrieval.
耳鸣是一种听觉感知，其特征是在没有任何外部声源的情况下感知到声音或噪音。基于神经生物学研究，人们普遍认为，大多数形式的耳鸣是由于听觉系统损伤导致的适应性不良性可塑性引起的。已经观察到下丘、丘脑和听觉皮层等听觉结构以及非听觉脑区发生了变化。然而，观察到的变化表现出很大的可变性，因此缺乏明确的结论。原因之一可能是在数据分析中选择了不均匀的组。
本研究的目的是通过静息态 EEG 的 LORETA 源分析，描绘参与窄带噪声和纯音耳鸣的神经网络之间的差异。
结果表明，窄带噪声耳鸣患者与纯音耳鸣患者在额外侧（BA10）、后扣带回和海马旁回的 delta、beta 和 gamma 频带的侧向额极存在差异。海马旁回-后扣带回的电流密度差异可能与负载有关，因为与纯音耳鸣相比，噪声样耳鸣构成了多个频率。外侧额极的差异可能与音高特异性记忆检索有关。
