Brai(2)n, TRI & Department of Neurosurgery, University Hospital Antwerp, Belgium.
Brai(2)n, TRI & Department of Neurosurgery, University Hospital Antwerp, Belgium.
Clin Neurophysiol. 2011 Mar;122(3):578-587. doi: 10.1016/j.clinph.2010.07.022. Epub 2010 Aug 30.
Tinnitus can be considered an auditory phantom percept, in which patients hear an internal sound in the absence of any external sound source, mimicking tonal memory. Tinnitus however can be perceived exclusively uni- or bilaterally.
The neurophysiological differences were investigated between unilateral and bilateral tinnitus using LORETA source localized resting state EEG recordings.
The difference between unilateral and bilateral tinnitus is reflected by high frequency activity (beta and gamma) in the superior prefrontal gurus, right parahippocampus, right angular gyrus and right auditory cortex. Unilateral tinnitus is characterized by contralateral beta2 in the superior prefrontal gyrus in comparison to bilateral tinnitus, but gamma in comparison to non-tinnitus subjects. Bilateral tinnitus has delta activity in the ventrolateral prefrontal cortex in comparison to unilateral tinnitus, and bilateral beta1 in comparison to non-tinnitus subjects. Bilateral tinnitus is also characterized by bilateral frontopolar beta1 activity.
Unilateral and bilateral tinnitus can be differentiated based on their resting state oscillation patterns: beta3 and gamma-band activity in the superior premotor cortex, parahippocampal area and angular gyrus seem to form the core of a spatial localization network involved in tinnitus.
These differences should be taken into account when evaluating functional neuroimaging data relating to tinnitus.
耳鸣可被视为一种听觉幻觉感知，患者在没有任何外部声源的情况下听到内部声音，模拟音调记忆。然而，耳鸣仅可单侧或双侧感知。
使用 LORETA 源定位静息态 EEG 记录研究单侧和双侧耳鸣的神经生理差异。
高频活动（β和γ）在额上回、右侧海马旁回、右侧角回和右侧听觉皮层中反映了单侧和双侧耳鸣之间的差异。与双侧耳鸣相比，单侧耳鸣的特征是额上回的对侧β2，但与非耳鸣受试者相比则为γ。与单侧耳鸣相比，双侧耳鸣在腹外侧前额叶皮层有δ活动，与非耳鸣受试者相比则有双侧β1。双侧耳鸣还表现为双侧额极β1活动。
单侧和双侧耳鸣可以通过其静息状态的振荡模式来区分：在运动前皮质、海马旁回和角回的β3 和γ 波段活动似乎形成了参与耳鸣的空间定位网络的核心。
在评估与耳鸣相关的功能神经影像学数据时，应考虑这些差异。
