Bányiová Katarína, Čupr Pavel, Kohoutek Jiří
RECETOX-Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.
Environ Sci Pollut Res Int. 2015 Jul;22(14):10713-20. doi: 10.1007/s11356-015-4252-x. Epub 2015 Mar 11.
Dermal absorption of the herbicide chlorotoluron was measured using ex vivo pig skin in Franz diffusion cells in an automated system. The steady-state flux was calculated, as well as the permeability coefficient, which is 0.0038 cm h(-1). The permeability coefficient (Kp) is a key factor when predicting human health risks resulting from dermal exposition to a substance. The experimental determination of this parameter filled data gaps regarding the dermal absorption of chlorotoluron. The experimental permeability coefficient was subsequently used to calculate the dermal absorbed dose during some exposure scenarios. Reference doses were revised, and screening risk assessment process was done to calculate the risks resulting from exposure to chlorotoluron. This refined new approach proved to be a useful tool for human health risk assessment in the areas with these herbicide applications. Graphical Abstract An experimentally refined tool to assess the risks of the human dermal exposure to herbicide chlorotoluron.
在自动化系统的Franz扩散池中，使用离体猪皮测量了除草剂绿麦隆的皮肤吸收情况。计算了稳态通量以及渗透系数，其值为0.0038 cm h⁻¹。渗透系数（Kp）是预测皮肤接触某种物质对人类健康风险时的关键因素。该参数的实验测定填补了绿麦隆皮肤吸收方面的数据空白。随后，利用实验渗透系数计算了某些暴露场景下的皮肤吸收剂量。修订了参考剂量，并进行了筛选风险评估过程，以计算接触绿麦隆所产生的风险。这种改进的新方法被证明是在使用这些除草剂的地区进行人类健康风险评估的有用工具。图形摘要：一种经过实验改进的工具，用于评估人类皮肤接触除草剂绿麦隆的风险。
