膦甲酸钠三钠，一种新型抗病毒化合物。

Trisodium phosphonoformate, a new antiviral compound.

作者信息

Helgstrand E, Eriksson B, Johansson N G, Lannerö B, Larsson A, Misiorny A, Norén J O, Sjöberg B, Stenberg K, Stening G, Stridh S, Oberg B

出版信息

Science. 1978 Sep 1;201(4358):819-21. doi: 10.1126/science.210500.

DOI:10.1126/science.210500

PMID:210500

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.

摘要

膦甲酸钠三钠可选择性抑制疱疹病毒诱导的无细胞DNA聚合酶活性。这种新型抑制剂在细胞培养中对1型和2型单纯疱疹病毒、伪狂犬病病毒及牛传染性鼻气管炎病毒具有抗病毒作用。它对豚鼠皮肤单纯疱疹病毒感染具有良好的治疗活性。