膦甲酸钠三钠对豚鼠皮肤疱疹病毒感染的治疗作用。
Therapeutic effect of trisodium phosphonoformate on cutaneous herpesvirus infection in guinea pigs.
作者信息
Alenius S, Dinter Z, Oberg B
出版信息
Antimicrob Agents Chemother. 1978 Sep;14(3):408-13. doi: 10.1128/AAC.14.3.408.
Abstract
When applied topically, trisodium phosphonoformate (PFA) displayed activity against established cutaneous herpesvirus infections in guinea pigs similar to that exhibited by the closely related phosphonoacetic acid (PAA); however, unlike PAA, PFA was not locally skin irritating. The therapeutic benefits of topical application of PFA were clearly evident when application was delayed for 48 h after virus inoculation, at which time lesions were well developed. The therapeutic effect was dependent on the concentration of PFA and the duration of treatment. PFA exhibited significant activity against established infections when administered intraperitoneally, although it was less effective via this systemic route than when applied topically.
摘要
局部应用时，膦甲酸钠（PFA）对豚鼠已建立的皮肤疱疹病毒感染显示出与密切相关的膦乙酸（PAA）相似的活性；然而，与PAA不同的是，PFA对皮肤没有局部刺激性。当在病毒接种后48小时延迟应用时，PFA局部应用的治疗益处明显显现，此时损伤已充分发展。治疗效果取决于PFA的浓度和治疗持续时间。腹腔内给药时，PFA对已建立的感染显示出显著活性，尽管通过这种全身途径给药的效果不如局部应用时有效。
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本文引用的文献
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