Reno J M, Lee L F, Boezi J A
Antimicrob Agents Chemother. 1978 Feb;13(2):188-92. doi: 10.1128/AAC.13.2.188.
Phosphonoformate was found to be an inhibitor of the deoxyribonucleic acid polymerase induced by the herpesvirus of turkeys. The apparent inhibition constants were 1 to 3 muM. Phosphonoformate was also able to block the replication in cell culture of Marek's disease herpesvirus, the herpesvirus of turkeys, and herpes simplex virus. It was as effective as phosphonoacetate. Phosphonoformate was not an effective inhibitor of a phosphonoacetate-resistant mutant of the herpesvirus of turkeys nor of its induced deoxyribonucleic acid polymerase.
膦甲酸被发现是火鸡疱疹病毒诱导的脱氧核糖核酸聚合酶的一种抑制剂。其表观抑制常数为1至3微摩尔。膦甲酸还能够阻断马立克氏病疱疹病毒、火鸡疱疹病毒和单纯疱疹病毒在细胞培养中的复制。其效果与膦乙酸相同。膦甲酸对火鸡疱疹病毒的膦乙酸抗性突变体及其诱导的脱氧核糖核酸聚合酶不是有效的抑制剂。
