Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, Amsterdam, The Netherlands.
Thromb J. 2010 Nov 4;8:16. doi: 10.1186/1477-9560-8-16.
Periodontitis is associated with cardiovascular diseases (CVD). In our previous studies a prothrombotic state has been observed in periodontitis, which contributes to the risk of CVD. The aim of this study was to investigate whether serum IgG levels against Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) in periodontitis were associated with a prothrombotic state.
Patients with moderate (n = 38) and severe periodontitis (n = 30) and controls (n = 24) were recruited. We explored correlations between serum anti-Aa and anti-Pg IgG and plasma levels of markers of prothrombotic state (von Willebrand Factor [vWF], prothrombin fragment 1+2 [F1+2], plasminogen activator inhibitor-1 [PAI-1] and D-dimer). Multivariate analyses were performed considering several major potential contributing factors.
Periodontitis patients showed higher anti-Aa IgG (p = 0.015) than controls but not for Pg (p = 0.320). In periodontitis patients, body mass index and anti-Aa IgG showed a positive correlation with vWF (β = 0.297, p = 0.010 and β = 0.248, p = 0.033 respectively).
In periodontitis, infection with Aa together with other well accepted risk factors for CVD, may play a role in increasing the risk for prothrombotic state.
牙周炎与心血管疾病（CVD）有关。在我们之前的研究中，观察到牙周炎存在促血栓形成状态，这增加了 CVD 的风险。本研究旨在探讨牙周炎患者血清中针对伴放线放线杆菌（Aa）和牙龈卟啉单胞菌（Pg）的 IgG 水平是否与促血栓形成状态有关。
招募了中度（n = 38）和重度牙周炎（n = 30）患者和对照组（n = 24）。我们探讨了血清抗-Aa 和抗-Pg IgG 与促血栓形成状态标志物（血管性血友病因子 [vWF]、凝血酶原片段 1+2 [F1+2]、纤溶酶原激活物抑制剂-1 [PAI-1]和 D-二聚体）之间的相关性。考虑到几个主要的潜在影响因素，进行了多变量分析。
牙周炎患者的抗-Aa IgG 水平高于对照组（p = 0.015），但对 Pg 则不然（p = 0.320）。在牙周炎患者中，体重指数和抗-Aa IgG 与 vWF 呈正相关（β = 0.297，p = 0.010 和 β = 0.248，p = 0.033）。
在牙周炎中，Aa 的感染以及其他公认的 CVD 风险因素可能在增加促血栓形成状态的风险方面发挥作用。
