Dikshit Shweta
Post Graduate Student, Department of Periodontology, Faculty of Dental Sciences, SGT University , Gurgaon, Haryana, India .
J Clin Diagn Res. 2015 Dec;9(12):ZC10-2. doi: 10.7860/JCDR/2015/14729.6922. Epub 2015 Dec 1.
Fibrinogen degradation products (e.g. D-dimer) arise from digested fibrin clots and fibrinogen. Elevated concentrations accompany activation of coagulation and fibrinolysis and indicate chronic inflammatory diseases. D-Dimer tests are a quick, noninvasive method to rule out abnormal clotting. Periodontitis strongly affects the haemostatic system and evokes a procoagulant state. Correlation of chronic periodontitis with early indicators of disease (biomarkers) might be useful.
The aim of the study was to examine whether the plasma D-dimer concentration reflects the progression of chronic periodontitis and the beneficial effect of periodontal therapy.
Forty randomly selected subjects were divided into four groups, Group I: 10 healthy subjects, Group II: 10 with mild periodontitis, Group III: 10 with moderate periodontitis, Group IV: 10 with severe periodontitis. After thorough dental and periodontal examination, 3 mL of venous blood was collected for measurement of fibrinogen degradation products.
The patients with moderate and chronic periodontitis exhibited high concentrations of D-dimer (mean value 434.98-535.52 mcg/mL), whereas subjects with mild or no periodontitis exhibited values of 329.78-211.29 mcg/mL. Concentrations of D-dimer were significantly reduced after therapy of all classes of periodontitis.
Periodontal treatment can reduce amount of D-dimer in the plasma. A higher than normal concentration is observed in chronic periodontitis.
纤维蛋白原降解产物（如D - 二聚体）源于被消化的纤维蛋白凝块和纤维蛋白原。其浓度升高伴随着凝血和纤维蛋白溶解的激活，并提示慢性炎症性疾病。D - 二聚体检测是一种快速、非侵入性的排除异常凝血的方法。牙周炎强烈影响止血系统并引发促凝状态。慢性牙周炎与疾病早期指标（生物标志物）之间的相关性可能具有重要意义。
本研究的目的是检验血浆D - 二聚体浓度是否反映慢性牙周炎的进展以及牙周治疗的有益效果。
随机选取40名受试者，分为四组，第一组：10名健康受试者；第二组：10名轻度牙周炎患者；第三组：10名中度牙周炎患者；第四组：10名重度牙周炎患者。在进行全面的口腔和牙周检查后，采集3 mL静脉血用于检测纤维蛋白原降解产物。
中度和重度牙周炎患者的D - 二聚体浓度较高（平均值为434.98 - 535.52 mcg/mL），而轻度或无牙周炎的受试者其浓度为329.78 - 211.29 mcg/mL。各类牙周炎治疗后，D - 二聚体浓度均显著降低。
牙周治疗可降低血浆中D - 二聚体的含量。慢性牙周炎患者的D - 二聚体浓度高于正常水平。
