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血清和唾液中 A. actinomycetemcomitans 特异性免疫球蛋白抗体与牙周炎的关系。

Association among serum and salivary A. actinomycetemcomitans specific immunoglobulin antibodies and periodontitis.

机构信息

Department of General Surgery and Surgical-Medical Specialties, School of Dentistry, University of Catania, Via S. Sofia 78, 95124, Catania, Italy.

Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Dentistry and Maxillofacial Surgery, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.

出版信息

BMC Oral Health. 2020 Oct 15;20(1):283. doi: 10.1186/s12903-020-01258-5.

DOI:10.1186/s12903-020-01258-5
PMID:33059645
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7565341/
Abstract

BACKGROUND

The aim of this study was to assess the association between serum and salivary Immunoglobulin (Ig) Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) specific antibodies in healthy controls (HC) and periodontitis (PT) patients. Furthermore, the objectives were to determine whether PT influenced serum A. actinomycetemcomitans specific antibodies and whether serum or salivary antibodies against A. actinomycetemcomitans IgG were mediated by serum high-sensitivity c-reactive protein (hs-CRP).

METHODS

Fifty-three patients with periodontitis and 48 HC were enrolled in the present study. Patients were regularly examined and characterized by clinical, salivary and blood samples analyses. A. actinomycetemcomitans IgA and IgG antibodies and hs-CRP were evaluated using a commercially available kit. The Spearman Correlation Test and Jonckheere-Terpstra Test were applied in order to assess the interdependence between serum A. actinomycetemcomitans IgG antibodies and clinical periodontal parameters. To evaluate the dependence of the serum and salivary A. actinomycetemcomitans IgG levels from possible confounders, univariate and multivariable linear regression analyses were performed.

RESULTS

Compared to HC, patients with PT had significantly higher IgA [serum: PT, 1.89 (1.2-2.2) EU vs HC, 1.37 (0.9-1.8) EU (p = 0.022); saliva: PT, 1.67 (1.4-2.1) EU vs HC, 1.42 (0.9-1.6) EU (p = 0.019)] and A. actinomycetemcomitans IgG levels [serum: PT, 2.96 (2.1-3.7) EU vs HC, 2.18 (1.8-2.1) EU (p < 0.001); saliva, PT, 2.19 (1.8-2.5) EU vs HC, 1.84 (1.4-2) EU (p = 0.028)]. In PT patients, serum A. actinomycetemcomitans IgG were associated with a proportional extent of PT and tooth loss (P-trend value< 0.001). The univariate regression analysis demonstrated that PT (p = 0.013) and high hs-CRP (p < 0.001) had a significant negative effect on serum and salivary A. actinomycetemcomitans IgG levels. The multivariate regression analysis showed that PT (p = 0.033), hs-CRP (p = 0.014) and BMI (p = 0.017) were significant negative predictors of serum A. actinomycetemcomitans IgG while hs-CRP (p < 0.001) and BMI (P = 0.025) were significant negative predictors of salivary A. actinomycetemcomitans IgG.

CONCLUSIONS

PT patients presented a significantly higher serum and salivary A. actinomycetemcomitans IgA and IgG compared to HC. There was a significant increase in serum A. actinomycetemcomitans IgG when patients presented a progressive extent of PT. Moreover, PT and hs-CRP were significant negative predictors of increased salivary and serum A. actinomycetemcomitans IgG levels.

TRIAL REGISTRATION

The study was retrospectively registered at clinicaltrials.gov ( NCT04417322 ).

摘要

背景

本研究旨在评估健康对照组（HC）和牙周炎（PT）患者血清和唾液中免疫球蛋白（Ig）聚集物放线共生放线杆菌（A. actinomycetemcomitans）特异性抗体之间的相关性。此外，本研究的目的是确定 PT 是否会影响血清 A. actinomycetemcomitans 特异性抗体，以及血清或唾液中针对 A. actinomycetemcomitans IgG 的抗体是否由血清高敏 C 反应蛋白（hs-CRP）介导。

方法

本研究纳入了 53 名牙周炎患者和 48 名 HC。对患者进行了常规检查，并通过临床、唾液和血液样本分析进行了特征描述。使用商业试剂盒评估 A. actinomycetemcomitans IgA 和 IgG 抗体和 hs-CRP。应用 Spearman 相关检验和 Jonckheere-Terpstra 检验来评估血清 A. actinomycetemcomitans IgG 抗体与临床牙周参数之间的相互关系。为了评估血清和唾液 A. actinomycetemcomitans IgG 水平是否受到可能的混杂因素的影响，进行了单变量和多变量线性回归分析。

结果

与 HC 相比，PT 患者的 IgA [血清：PT，1.89（1.2-2.2）EU 比 HC，1.37（0.9-1.8）EU（p=0.022）；唾液：PT，1.67（1.4-2.1）EU 比 HC，1.42（0.9-1.6）EU（p=0.019）]和 A. actinomycetemcomitans IgG 水平 [血清：PT，2.96（2.1-3.7）EU 比 HC，2.18（1.8-2.1）EU（p<0.001）；唾液，PT，2.19（1.8-2.5）EU 比 HC，1.84（1.4-2）EU（p=0.028）]显著更高。在 PT 患者中，血清 A. actinomycetemcomitans IgG 与 PT 的程度和牙齿缺失呈比例相关（P 趋势值<0.001）。单变量回归分析表明，PT（p=0.013）和高 hs-CRP（p<0.001）对血清和唾液 A. actinomycetemcomitans IgG 水平有显著的负面影响。多变量回归分析显示，PT（p=0.033）、hs-CRP（p=0.014）和 BMI（p=0.017）是血清 A. actinomycetemcomitans IgG 的显著负预测因子，而 hs-CRP（p<0.001）和 BMI（p=0.025）是唾液 A. actinomycetemcomitans IgG 的显著负预测因子。

结论

与 HC 相比，PT 患者的血清和唾液中 A. actinomycetemcomitans IgA 和 IgG 明显更高。当患者出现进展性牙周炎时，血清 A. actinomycetemcomitans IgG 显著增加。此外，PT 和 hs-CRP 是血清和唾液中 A. actinomycetemcomitans IgG 水平升高的显著负预测因子。

试验注册

该研究在 clinicaltrials.gov 上进行了回顾性注册（NCT04417322）。

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