Gaxatte Cédric, Daroux Maïté, Bloch Jennifer, Puisieux François, Deramecourt Vincent, Boulanger Eric
Pôle de gérontologie, CHRU de Lille, 23, rue des Bateliers, 59037 Lille cedex, France.
Nephrol Ther. 2011 Feb;7(1):10-7. doi: 10.1016/j.nephro.2010.09.001. Epub 2010 Nov 2.
Ageing of the population leads to an increase of cognitive disorders and chronic renal failure incidence. Compared to the general population, prevalence of cognitive impairment is more important in renal failure patients, especially in dialyzed patients. No direct link has been established between renal failure and cognitive impairment. The care of older and older patients and the high frequency of vascular risk factors, in particular hypertension and diabetes, partially explain the prevalence of vascular dementia and Alzheimer disease in this population. Other factors as the anemia, phosphocalcic metabolism disorders facilitate the cognitive impairment. The present work reviews the links existing between chronic renal failure and cognitive impairment.
人口老龄化导致认知障碍和慢性肾衰竭发病率增加。与普通人群相比，认知障碍在肾衰竭患者中更为普遍，尤其是在透析患者中。肾衰竭与认知障碍之间尚未建立直接联系。老年患者护理以及血管危险因素（特别是高血压和糖尿病）的高发生率，部分解释了该人群中血管性痴呆和阿尔茨海默病的患病率。其他因素如贫血、钙磷代谢紊乱也会促进认知障碍。本研究综述了慢性肾衰竭与认知障碍之间的现有联系。
