Loumaye E, Billion J M, Mine J M, Psalti I, Pensis M, Thomas K
Department of Obstetrics and Gynecology, University of Louvain, Brussels, Belgium.
Fertil Steril. 1990 Feb;53(2):295-301. doi: 10.1016/s0015-0282(16)53284-1.
A clomiphene citrate (CC) challenge test was carried out in 114 patients to evaluate the capacity of this test to predict the patient's individual response to controlled ovarian hyperstimulation (COH) performed with a gonadotropin-releasing hormone agonist and human menopausal gonadotrophins (hMG) for in vitro fertilization. The sum of follicle-stimulating hormone measured before and after CC intake, is the parameter that correlated best with subsequent response to COH. The upper limit of the reference value for this parameter, established by considering the CC challenge test performed on 26 patients who became pregnant, was 26.03 mIU/mL. Twenty patients who presented a CC challenge test result above the reference value were compared with patients with a normal test result. For these 20 patients, COH required more hMG and was cancelled in 25% of the cases (instead of 1% in the control group). The number of follicles aspirated, oocytes retrieved, and embryos obtained were on average six times lower than in patients with a CC challenge test result within the reference value, and no pregnancy was obtained. We concluded that CC challenge test provides a reliable individual prognosis for the ovarian response to COH.
对114例患者进行了枸橼酸氯米芬（CC）激发试验，以评估该试验预测患者对使用促性腺激素释放激素激动剂和人绝经期促性腺激素（hMG）进行体外受精的控制性卵巢刺激（COH）的个体反应的能力。服用CC前后测得的促卵泡生成素之和是与随后对COH的反应相关性最好的参数。通过对26例已怀孕患者进行的CC激发试验确定的该参数参考值上限为26.03 mIU/mL。将20例CC激发试验结果高于参考值的患者与试验结果正常的患者进行比较。对于这20例患者，COH需要更多的hMG，并且25%的病例取消了COH（而对照组为1%）。平均而言，抽吸的卵泡数、获取的卵母细胞数和获得的胚胎数比CC激发试验结果在参考值范围内的患者低六倍，且未获得妊娠。我们得出结论，CC激发试验为卵巢对COH的反应提供了可靠的个体预后。
