帕金森病听觉皮层的成对脉冲抑制及其对患者临床特征的依赖性。
Paired-pulse inhibition in the auditory cortex in Parkinson's disease and its dependence on clinical characteristics of the patients.
机构信息
Department of Brain Physiology, Bogomoletz Institute of Physiology, 01024 Kiev, Ukraine.
出版信息
Parkinsons Dis. 2010 Nov 1;2011:342151. doi: 10.4061/2011/342151.
We aimed to determine the value of the paired-pulse inhibition (PPI) in the auditory cortex in patients with Parkinson's disease (PD) and analyze its dependence on clinical characteristics of the patients. The central (Cz) auditory evoked potentials were recorded in 58 patients with PD and 22 age-matched healthy subjects. PPI of the N1/P2 component was significantly (P < .001) reduced for interstimulus intervals 500, 700, and 900 ms in patients with PD compared to control subjects. The value of PPI correlated negatively with the age of the PD patients (P < .05), age of disease onset (P < .05), body bradykinesia score (P < .01), and positively with the Mini Mental State Examination (MMSE) cognitive score (P < .01). Negative correlation between value of PPI and the age of the healthy subjects (P < .05) was also observed. Thus, results show that cortical inhibitory processes are deficient in PD patients and that the brain's ability to carry out the postexcitatory inhibition is age-dependent.
我们旨在确定帕金森病（PD）患者听觉皮层中的配对脉冲抑制（PPI）的价值，并分析其对患者临床特征的依赖性。在 58 名 PD 患者和 22 名年龄匹配的健康受试者中记录了中央（Cz）听觉诱发电位。与对照组相比，PD 患者的 N1/P2 成分的刺激间隔为 500、700 和 900 ms 时，PPI 显著降低（P<.001）。PPI 值与 PD 患者的年龄（P<.05）、疾病发病年龄（P<.05）、身体运动迟缓评分（P<.01）呈负相关，与简易精神状态检查（MMSE）认知评分（P<.01）呈正相关。还观察到 PPI 值与健康受试者年龄之间的负相关（P<.05）。因此，结果表明皮质抑制过程在 PD 患者中存在缺陷，并且大脑进行兴奋性后抑制的能力是年龄依赖性的。
Zotero 插件