Institute of Movement and Neurosciences, German Sport University Cologne, Cologne, Germany.
Horm Metab Res. 2010 Dec;42(13):982-6. doi: 10.1055/s-0030-1267950. Epub 2010 Nov 4.
Studies have shown that, depending on intensity, endurance exercise increases neurotrophins and thereby induces neuroplasticity. However, data on the effect of acute resistance exercise at different intensities on neurotrophins is not yet available. Thus, we conducted 2 trials to determine the serum concentrations of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), and insulin-like growth factor (IGF-1) before and after a low or high intensity resistance exercise in 11 healthy humans. Exercise load was related to 3 repetitions of maximal effort isokinetic work involving knee extension under alternating concentric and eccentric conditions for muscle work at a velocity of 60°s-1 registered during a familiarization session. The torque angle diagrams from these 3 repetitions were averaged and displayed as target curves in the test sessions, the intensity of resistance exercise was set at 40% (trial: R1) or 110% (trial: R2) of the averaged individual maximal effort curve, respectively. After resistance exercise, serum IGF-1 was increased significantly (p<0.01) by 28% in R1 and 16% in R2 compared to pre-exercise levels. Resistance exercise did not increase serum VEGF at any time point. Serum BDNF increased during exercise compared to post-exercise, but did not achieve significant difference from pre-exercise values. The present study shows that either low or high resistance exercise increases levels of IGF-1, but not of BDNF or VEGF. This finding is of importance for health promotion by means of resistance exercise because circulating serum IGF-1 has been demonstrated to mediate positive effects of exercise on brain functions.
研究表明，耐力运动可根据强度增加神经营养因子，从而诱导神经可塑性。然而，目前尚无关于不同强度急性抗阻运动对神经营养因子影响的数据。因此，我们进行了两项试验，以确定 11 名健康人在低强度或高强度抗阻运动前后血清脑源性神经营养因子（BDNF）、血管内皮生长因子（VEGF）和胰岛素样生长因子（IGF-1）的浓度。运动负荷与 3 次最大努力的等速向心和离心工作有关，在熟悉过程中记录了以 60°s-1 的速度进行的肌肉工作。这 3 次重复的扭矩角度图被平均，并在测试过程中显示为目标曲线，抗阻运动的强度分别设定为平均个体最大努力曲线的 40%（试验：R1）或 110%（试验：R2）。与运动前相比，R1 中 IGF-1 增加了 28%，R2 中 IGF-1 增加了 16%，血清 IGF-1 显著增加（p<0.01）。在任何时间点，抗阻运动都不会增加血清 VEGF。与运动后相比，运动期间血清 BDNF 增加，但与运动前值无显著差异。本研究表明，低强度或高强度抗阻运动均可增加 IGF-1 水平，但不能增加 BDNF 或 VEGF 水平。这一发现对抗阻运动促进健康具有重要意义，因为循环血清 IGF-1 已被证明介导运动对大脑功能的积极影响。
