Mesynthes Limited, Lower Hutt 5040, New Zealand.
J Biomed Mater Res B Appl Biomater. 2011 Jan;96(1):67-75. doi: 10.1002/jbm.b.31740.
Ovine forestomach matrix (OFM) is a native and functional decellularized extracellular matrix biomaterial that supports cell adhesion and proliferation and is remodeled during the course of tissue regeneration. Small angle X-ray scattering demonstrated that OFM retains a native collagen architecture (d spacing = 63.5 ± 0.2 nm, orientation index = 20°). The biophysical properties of OFM were further defined using ball-burst, uniaxial and suture retention testing, as well as a quantification of aqueous permeability. OFM biomaterial was relatively strong (yield stress = 10.15 ± 1.81 MPa) and elastic (modulus = 0.044 ± 0.009 GPa). Lamination was used to generate new OFM-based biomaterials with a range of biophysical properties. The resultant multi-ply OFM biomaterials had suitable biophysical characteristics for clinical applications where the grafted biomaterial is under load.
绵羊前胃基质（OFM）是一种天然的、具有功能的去细胞细胞外基质生物材料，可支持细胞黏附和增殖，并在组织再生过程中进行重塑。小角 X 射线散射表明，OFM 保留了天然的胶原结构（d 间距=63.5±0.2nm，取向指数=20°）。使用球爆裂、单轴和缝线保持测试以及对水渗透性的定量分析，进一步定义了 OFM 的生物物理特性。OFM 生物材料相对较强（屈服应力=10.15±1.81MPa）且有弹性（模量=0.044±0.009GPa）。采用层压工艺生成具有一系列生物物理特性的新型 OFM 基生物材料。所得的多层 OFM 生物材料具有适合临床应用的生物物理特性，适用于承受负载的移植生物材料。
