Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
J Am Geriatr Soc. 2010 Nov;58(11):2055-62. doi: 10.1111/j.1532-5415.2010.03145.x.
To determine the association between loss of muscle strength, mass, and quality and functional limitation and physical disability in older men.
Cross-sectional study of older men participating in the Concord Health and Ageing in Men Project (CHAMP).
Elderly men living in a defined geographical region in Sydney, Australia.
One thousand seven hundred five community-dwelling men aged 70 and older who participated in the baseline assessments of CHAMP.
Upper and lower extremity strength were measured using dynamometers for grip and quadriceps strength. Appendicular skeletal lean mass was assessed using dual X-ray absorptiometry. Muscle quality was defined as the ratio of strength to mass in upper and lower extremities. For each parameter, subjects in the lowest 20% of the distribution were defined as below normal. Functional limitation was assessed according to self-report and objective lower extremity performance measures. Physical disability was measured according to self-report questionnaire.
After adjusting for important confounders, the prevalence ratio (PR) for poor quadriceps strength and self-reported functional limitation was 1.91 (95% confidence interval (CI) = 1.10-2.40); for performance-based functional limitation the PR was 1.81 (95% CI = 1.45-2.24). The adjusted PR for poor grip strength and physical disability in instrumental activities of daily living (IADLs) was 1.37 (95% CI = 1.20-1.56). The adjusted PR for low skeletal lean mass (adjusted for fat mass) and physical disability in basic activities of daily living was 2.08 (95% CI = 1.37-3.15). For muscle quality, the PR for lower extremity specific force and functional limitation and physical disability was stronger than upper extremity specific force.
Muscle strength is the single best measure of age-related muscle change and is associated with physical disability in IADLs and functional limitation.
确定肌肉力量、质量和功能的丧失与老年人功能障碍和身体残疾之间的关系。
参与 Concord 健康与老年人男性项目（CHAMP）的老年男性的横断面研究。
澳大利亚悉尼一个特定地理区域的老年男性。
1705 名年龄在 70 岁及以上、参加 CHAMP 基线评估的社区居住男性。
使用测力计测量上肢和下肢力量，以测量握力和股四头肌力量。使用双能 X 线吸收法评估四肢骨骼瘦体重。肌肉质量定义为上肢和下肢力量与质量的比值。对于每个参数，分布最低 20%的受试者被定义为低于正常水平。根据自我报告和客观下肢运动表现测量来评估功能障碍。根据自我报告问卷来衡量身体残疾。
在调整了重要的混杂因素后，股四头肌力量差和自我报告的功能障碍的比值比（PR）为 1.91（95%置信区间（CI）=1.10-2.40）；对于基于表现的功能障碍，PR 为 1.81（95% CI = 1.45-2.24）。握力差和日常活动工具性活动（IADLs）的身体残疾的调整后 PR 为 1.37（95% CI = 1.20-1.56）。调整后的瘦体重（按脂肪量调整）低和基本日常生活活动的身体残疾的 PR 为 2.08（95% CI = 1.37-3.15）。对于肌肉质量，下肢特定力量与功能障碍和身体残疾的 PR 强于上肢特定力量。
肌肉力量是与年龄相关的肌肉变化的最佳单一测量指标，与 IADLs 和功能障碍相关的身体残疾相关。
