Department of Dermatology, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Fetscherstraße 74, Dresden 01307, Germany.
Br J Dermatol. 2011 Feb;164(2):291-307. doi: 10.1111/j.1365-2133.2010.10118.x.
Despite the fact that ultraviolet (UV) light exposure is the most important risk factor for cutaneous squamous cell carcinoma (SCC) there is an ongoing debate concerning the relationship between cumulative work-related UV exposure and SCC occurrence.
To analyse comprehensively the relationship between work-related UV exposure and SCC risk.
We conducted a systematic electronic literature search in PubMed (up to 5 May 2010) supplemented by a hand search, which identified 18 relevant studies that were included in the review. Data abstraction and study quality assessment was done independently by two reviewers. Maximally adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of all included studies were pooled in a random-effects meta-analysis. Sensitivity analysis included meta-regression on study-specific covariates to explore the robustness of the results and to identify sources of heterogeneity between studies. Eighteen studies (six cohort studies, 12 case-control studies) met the eligibility criteria and were included in the systematic review.
Sixteen studies (89%) found an increased risk of SCC in individuals with occupational UV light exposure compared with individuals without occupational UV light exposure, reaching statistical significance in 12 studies. Two studies found no association between occupational UV light exposure and SCC occurrence. The pooled OR (95% CI) was 1·77 (1·40-2·22) and did not differ significantly between cohort studies [OR (95% CI): 1·68 (1·08-2·63)] and case-control studies [OR (95% CI): 1·77 (1·37-2·30)]. Meta-regression analyses suggested an increasing strength of the association between occupational UV light exposure and SCC risk with decreasing latitude.
In summary, there is consistent epidemiological evidence for a positive association between occupational UV light exposure and SCC risk.
尽管紫外线（UV）暴露是皮肤鳞状细胞癌（SCC）最重要的危险因素，但关于累积职业性 UV 暴露与 SCC 发生之间的关系仍存在争议。
全面分析职业性 UV 暴露与 SCC 风险之间的关系。
我们在 PubMed 上进行了系统的电子文献检索（截至 2010 年 5 月 5 日），并辅以手工检索，共确定了 18 项相关研究，这些研究均纳入了本综述。两名评审员独立进行数据提取和研究质量评估。采用随机效应荟萃分析对所有纳入研究的最大调整比值比（OR）及其相应的 95%置信区间（CI）进行汇总。敏感性分析包括对研究特异性协变量进行荟萃回归，以探索结果的稳健性并确定研究之间异质性的来源。符合纳入标准的研究共 18 项（6 项队列研究，12 项病例对照研究），纳入了系统性评价。
16 项（89%）研究发现，与无职业性 UV 光暴露者相比，职业性 UV 光暴露者 SCC 风险增加，其中 12 项研究具有统计学意义。有 2 项研究未发现职业性 UV 光暴露与 SCC 发生之间存在关联。汇总 OR（95%CI）为 1.77（1.40-2.22），队列研究 [OR（95%CI）：1.68（1.08-2.63）] 和病例对照研究 [OR（95%CI）：1.77（1.37-2.30）] 之间无显著差异。荟萃回归分析提示，随着纬度的降低，职业性 UV 光暴露与 SCC 风险之间的关联强度逐渐增加。
总之，职业性 UV 光暴露与 SCC 风险之间存在一致性的流行病学证据。
