Université de Reims Champagne Ardenne, Laboratoire de Chimie Thérapeutique, 51 Rue Cognacq Jay, 51100 Reims, France.
J Pharm Pharmacol. 2010 Dec;62(12):1669-75. doi: 10.1111/j.2042-7158.2010.01190.x.
The therapeutic benefits of argan oil consumption have been claimed by natives of Morocco and explorers for more than eight centuries. However, argan oil has remained unresearched for a long time. Traditionally, argan oil has been well known for its cardioprotective properties and it is also used in the treatment of skin infections. Argan oil is principally composed of mono-unsaturated (up to 80%) and saturated (up to 20%) fatty acids. As minor components, it contains polyphenols, tocopherols, sterols, squalene, and triterpene alcohols. Together with the mono-unsaturated fatty acids, these minor components are likely to be responsible for its beneficial effects. This review aims to present an overview of the known pharmacological properties of argan oil.
Antiproliferative, antidiabetic, and cardiovascular-protective effects of argan oil have been particularly actively evaluated over the last 5 years in order to build on phytochemical studies that indicate the presence of large amounts of possibly pharmacologically active compounds.
This review shows that a lack of clinical data constitutes a serious weakness in our knowledge about argan oil, therefore it is difficult to correlate the reported pharmacological activities to any potential clinical relevance.
摩洛哥当地人和探险家声称，角鲨烷油的治疗益处已被证实超过 800 年。然而，角鲨烷油长期以来一直未被研究。传统上，角鲨烷油以其心脏保护特性而闻名，也用于治疗皮肤感染。角鲨烷油主要由单不饱和（高达 80%）和饱和（高达 20%）脂肪酸组成。作为次要成分，它含有多酚、生育酚、甾醇、角鲨烯和三萜醇。这些次要成分与单不饱和脂肪酸一起，可能是其有益效果的原因。这篇综述旨在概述已知的角鲨烷油的药理学特性。
在过去的 5 年中，角鲨烷油的抗增殖、抗糖尿病和心血管保护作用得到了特别积极的评估，以便在植物化学研究的基础上进一步研究，这些研究表明存在大量可能具有药理活性的化合物。
这篇综述表明，缺乏临床数据是我们对角鲨烷油知识的严重缺陷，因此很难将报道的药理活性与任何潜在的临床相关性联系起来。
