“人生就像高速公路”：胞质分裂过程中的膜转运。
'Life is a highway': membrane trafficking during cytokinesis.
机构信息
Department of Biology, Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.
出版信息
Traffic. 2011 Mar;12(3):247-51. doi: 10.1111/j.1600-0854.2010.01139.x. Epub 2010 Nov 24.
Abstract
Cytokinesis, the final stage of the cell cycle, is an essential step toward the formation of two viable daughter cells. In recent years, membrane trafficking has been shown to be important for the completion of cytokinesis. Vesicles originating from both the endocytic and secretory pathways are known to be shuttled to the plasma membrane of the ingressing cleavage furrow, delivering membrane and proteins to this dynamic region. Advances in cell imaging have led to exciting new discoveries regarding vesicle movement in living cells. Recent work has revealed a significant role for membrane trafficking, as controlled by regulatory proteins, during cytokinesis in animal cells. The endocytic and secretory pathways as well as motor proteins are revealed to be essential in the delivery of vesicles to the cleavage furrow during cytokinesis.
摘要
细胞分裂是细胞周期的最后一个阶段，是形成两个可行的子细胞的关键步骤。近年来，膜运输已被证明对细胞分裂的完成很重要。已知起源于内吞作用和分泌途径的囊泡被运送到进入的分裂沟的质膜，将膜和蛋白质输送到这个动态区域。细胞成像技术的进步使得人们对活细胞中囊泡运动有了令人兴奋的新发现。最近的研究揭示了在动物细胞的细胞分裂过程中，膜运输（受调节蛋白控制）的重要作用。内吞作用和分泌途径以及马达蛋白对于在细胞分裂过程中将囊泡递送到分裂沟是必不可少的。
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