Strickland Laila I, Burgess David R
Boston College, Chestnut Hill, MA, USA.
Trends Cell Biol. 2004 Mar;14(3):115-8. doi: 10.1016/j.tcb.2004.01.006.
The molecular mechanisms underlying targeted deposition of new membrane at the advancing furrow of a dividing cell have long been intriguing to cell biologists. Three recent studies have made use of Drosophila cellularization to explore current questions in this field. These findings indicate that both the secretory pathway and endosomal recycling contribute membrane to the advancing furrow. Furthermore, new work reveals that vesicles derived from the Rab11 recycling endosome (RE) promote actin remodeling at the furrow.
长期以来，细胞生物学家一直对新膜在分裂细胞前进沟处的靶向沉积背后的分子机制很感兴趣。最近的三项研究利用果蝇细胞化来探索该领域当前的问题。这些发现表明，分泌途径和内体循环都为前进沟提供膜。此外，新的研究表明，来自Rab11循环内体（RE）的囊泡促进沟处的肌动蛋白重塑。
