双侧胸腔积液和间质性肺病作为奇金氏病的不常见表现：病例报告及文献复习。
Bilateral pleural effusion and interstitial lung disease as unusual manifestations of Kikuchi-Fujimoto disease: case report and literature review.
机构信息
Mendaro Hospital, Gipuzkoa, Spain.
出版信息
BMC Pulm Med. 2010 Nov 5;10:54. doi: 10.1186/1471-2466-10-54.
BACKGROUND
Kikuchi-Fujimoto's disease (KFD), also called histiocytic necrotizing lymphadenitis, is a rare, idiopathic and self-limited condition usually characterized by cervical lymphadenopathy and fever, most often affecting young patients. Aetiology is unknown. Differential diagnosis includes mainly malignant lymphoma, tuberculous lymphadenitis and systemic lupus erythematosus (SLE), so early diagnosis is crucial. Pleuropulmonary involvement due to isolated KFD has been seldom reported.
CASE PRESENTATION
a 32-year-old man, on treatment for iatrogenic hypothyroidism, was admitted due to high grade fever and painful cervical lymphadenopathies. KFD was diagnosed by lymph node biopsy. Some days after admission the patient got worse, he developed generalized lymphadenopathy, bilateral pleural effusion and interstitial lung disease. All of them resolved with prednisone and after two years of following up he remains asymptomatic and without evidence of any other associated disease.
CONCLUSION
Pleural effusion and interstitial lung disease are very uncommon manifestations of KFD. In our experience, treatment with oral prednisone was effective.
背景
Kikuchi-Fujimoto 病（KFD），又称组织细胞性坏死性淋巴结炎，是一种罕见的、特发性和自限性疾病，通常表现为颈淋巴结病和发热，最常影响年轻患者。病因不明。鉴别诊断主要包括恶性淋巴瘤、结核性淋巴结炎和系统性红斑狼疮（SLE），因此早期诊断至关重要。由于孤立性 KFD 引起的胸膜肺受累很少见。
病例介绍
一名 32 岁男性，因医源性甲状腺功能减退症正在接受治疗，因高热和颈淋巴结痛入院。通过淋巴结活检诊断为 KFD。入院后几天，患者病情恶化，出现全身淋巴结病、双侧胸腔积液和间质性肺病。泼尼松治疗后所有症状均得到缓解，两年随访后患者无症状，无其他相关疾病证据。
结论
胸腔积液和间质性肺病是 KFD 非常罕见的表现。根据我们的经验，口服泼尼松治疗有效。
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