[豚鼠眼睛对形觉剥夺性近视的易感性及其与年龄相关的恢复情况]

Zhi Zhi-na, Yang Ting-zhen, Xiong Shi-bo, Jiang Li-qin, Pan Miao-zhen, Qu Jia, Zhou Xian-tian

Eye Hospital, Wenzhou Medical College. Wenzhou, China.

Zhonghua Yan Ke Za Zhi. 2010 Jul;46(7):641-5.

OBJECTIVE

Young guinea pigs are susceptible to become myopic during form deprivation. They can also quickly recover from the myopia after removal of the form deprivation. This study investigated whether mature guinea pigs are sensitive to form deprivation and its refractive recovery from deprivation myopia.

METHODS

It was an experimental study. Thirty-nine guinea pigs were arranged to 3 groups according to age. Group 1: 9-week old (n = 18). Group 2: 12-week old (n = 10). Group 3: 15-week old (n = 11). All the animals were performed refraction measurement prior to the experiment, then wore a facemask that covered one randomly assigned eye for three weeks. The masks were then removed and refraction was measured in both eyes immediately, 2 and 7 days after.

RESULTS

After form deprivation, the refraction of the MFD (monocular form deprivation) eyes shifted to myopia, which had significant difference compared to the unmasked eye in all the groups (t = -5.691, -2.203, -2.760; P < 0.05), the relative myopia compared to the unmasked eye in 9 weeks old animals were (-2.53 ± 1.89) D, 12 weeks old (-1.43 ± 1.57) D, 15 weeks old (-0.60 ± 1.48) D. There was significant difference between 9 weeks old animals and 15 weeks old animal in the refractive error right after the form deprivation (F = 2.823, P < 0.05). And the distribution of refractive error tended to lower degree of myopia as the guinea pigs grew older. None of the three groups showed significant reduction in relative refractive error during the recovery, but a trend of recovery was found in 9 weeks old animals.

CONCLUSIONS

The guinea pigs are sensitive to the form deprivation even when they are sexual mature, but both the susceptibility and the ability of recovery decrease as they grow older but in different patterns. The ability of recovery in short term (7 days) diminishes when guinea pig is older than 12 weeks while the sensitivity to form deprivation last until 15 w.

目的

幼年豚鼠在形觉剥夺期间易患近视。在去除形觉剥夺后，它们也能迅速从近视中恢复。本研究调查了成年豚鼠对形觉剥夺及其从剥夺性近视恢复屈光状态的敏感性。

方法

这是一项实验研究。39只豚鼠按年龄分为3组。第1组：9周龄（n = 18）。第2组：12周龄（n = 10）。第3组：15周龄（n = 11）。所有动物在实验前进行屈光测量，然后佩戴覆盖一只随机分配眼睛的面罩3周。然后取下面罩，立即、2天和7天后测量双眼的屈光。

结果

形觉剥夺后，单眼形觉剥夺（MFD）眼的屈光向近视偏移，在所有组中与未遮盖眼相比有显著差异（t = -5.691，-2.203，-2.760；P < 0.05），9周龄动物与未遮盖眼相比的相对近视度数为（-2.53 ± 1.89）D，12周龄为（-1.43 ± 1.57）D，15周龄为（-0.60 ± 1.48）D。形觉剥夺后即刻，9周龄动物与15周龄动物的屈光不正存在显著差异（F = 2.823，P < 0.05）。随着豚鼠年龄增长，屈光不正分布倾向于近视程度降低。三组在恢复过程中均未显示相对屈光不正有显著降低，但在9周龄动物中发现有恢复趋势。