Lindvall O, Brundin P, Widner H, Rehncrona S, Gustavii B, Frackowiak R, Leenders K L, Sawle G, Rothwell J C, Marsden C D
Department of Neurology, University Hospital, Lund, Sweden.
Science. 1990 Feb 2;247(4942):574-7. doi: 10.1126/science.2105529.
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.
神经移植可在帕金森病动物模型中恢复纹状体多巴胺能神经传递。现已表明，从妊娠8至9周龄的人类胎儿获取的中脑多巴胺神经元，能在人脑中存活，并使一名患有严重特发性帕金森病的患者获得显著且持续的症状缓解。通过立体定向手术将这些移植物单侧植入壳核，正电子发射断层扫描结合6-L-[18F]氟多巴评估显示，移植物恢复了移植区域的多巴胺合成与储存。这种神经化学变化伴随着患者严重的强直和运动迟缓在治疗上的显著减轻，以及患者在最佳药物治疗期间病情波动（“开-关”现象）的明显减少。临床改善在移植对侧最为明显。
