Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan.
Neurosci Lett. 2011 Jan 10;487(3):421-5. doi: 10.1016/j.neulet.2010.10.069. Epub 2010 Nov 3.
The aim of this study was to identify brain regions associated with performance on various measures of the clock drawing test (CDT) using magnetic resonance imaging (MRI).We recruited 48 participants (four healthy, eight with mild cognitive impairment and 36 with Alzheimer's disease). Multiple regression analyses identified relationships between each CDT scoring system (Shulman CDT, Rouleau CDT and CLOX1) and regional gray matter (GM) volume.CDT scores were positively correlated with regional GM volume in the right parietal lobe for all three CDT scoring systems. In addition, CDT scores were positively correlated with regional GM volume in the bilateral posterior temporal lobes for the Shulman CDT, in the right posterior inferior temporal lobe for the Rouleau CDT and in the right posterior superior temporal lobe for the CLOX1.Although the scoring systems share commonalities, each CDT scoring system may reflect different areas of brain damage.
本研究旨在利用磁共振成像（MRI）确定与各种画钟测验（CDT）评分相关的脑区。我们招募了 48 名参与者（4 名健康人，8 名轻度认知障碍患者和 36 名阿尔茨海默病患者）。多元回归分析确定了每个 CDT 评分系统（Shulman CDT、Rouleau CDT 和 CLOX1）与局部灰质（GM）体积之间的关系。对于所有三个 CDT 评分系统，CDT 评分与右侧顶叶的局部 GM 体积呈正相关。此外，Shulman CDT 评分与双侧后颞叶、Rouleau CDT 评分与右侧下颞叶、CLOX1 评分与右侧上颞叶的局部 GM 体积呈正相关。虽然评分系统有共同之处，但每个 CDT 评分系统可能反映了不同的脑损伤区域。
