Department of Psychiatry, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
Fertil Steril. 2011 Feb;95(2):711-6.e1. doi: 10.1016/j.fertnstert.2010.10.004. Epub 2010 Nov 5.
To examine the emotional, sexual, physical, and quality-of-life (QOL) impact on infertile women awaiting oocyte donation.
Cross-sectional cohort study.
Cancer center and reproductive medicine center.
PATIENT(S): Fifty infertile women awaiting oocyte donation, enrolled from October 2006 to February 2009.
INTERVENTION(S): Woman awaiting oocyte donation completed a one-time survey of empirical measures and exploratory items.
MAIN OUTCOME MEASURE(S): Reproductive concerns, depression, sexual function, distress, menopausal symptoms, physical and mental health, and relationship satisfaction.
RESULT(S): Of the participants, 33% were clinically depressed (Center for Epidemiologic Studies Depression Scale), and 59% had high levels of distress (Impact of Events Scale). The cohort's mean Female Sexual Function Index score (24.09) was below the cutoff value (26.55), indicating sexual dysfunction. Relationship satisfaction (Abbreviated Dyadic Adjustment Scale) scores were comparable to the population norm. Patients had good physical QOL but below average mental QOL (Medical Outcomes SF-12 Health Survey). Sixty-four percent were concerned about long-term effects of treatment, although 94% were grateful for reproductive assistance options and described parenthood as providing enrichment, happiness, and meaning to their lives.
CONCLUSION(S): Infertility can negatively impact sexual function, QOL, and emotional well-being. Quantitative empirical measures and qualitative data have shown that these women experienced and recognized the emotional toll of reproductive assistance. Despite concerns about the long-term effects of treatment, participants were grateful for this third-party parenting option.
探讨卵母细胞捐赠等待期不孕女性的情绪、性、身体和生活质量（QOL）影响。
横断面队列研究。
癌症中心和生殖医学中心。
50 名等待卵母细胞捐赠的不孕女性，于 2006 年 10 月至 2009 年 2 月入选。
等待卵母细胞捐赠的女性完成了一次经验性措施和探索性项目的调查。
生殖关注、抑郁、性功能、痛苦、更年期症状、身心健康和关系满意度。
在参与者中，33%有临床抑郁（流行病学研究中心抑郁量表），59%有高程度的痛苦（事件影响量表）。该队列的平均女性性功能指数得分（24.09）低于临界值（26.55），表明存在性功能障碍。关系满意度（简短双调整适量表）得分与人群正常水平相当。患者有良好的身体 QOL，但心理健康水平低于平均水平（医疗结果 SF-12 健康调查）。64%的患者担心治疗的长期影响，尽管 94%的患者对生殖辅助选择表示感激，并描述为人父母为他们的生活带来了充实、幸福和意义。
不孕可能对性功能、QOL 和情绪健康产生负面影响。定量实证措施和定性数据表明，这些女性经历并认识到生殖辅助的情绪代价。尽管对治疗的长期影响存在担忧，但参与者对这种第三方育儿选择表示感激。
