Cai Huaqing, Reinisch Karin, Ferro-Novick Susan
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06519, USA.
Dev Cell. 2007 May;12(5):671-82. doi: 10.1016/j.devcel.2007.04.005.
Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.
拴系因子已被证明可与Rabs和SNAREs相互作用，最近还发现其与衣被蛋白相互作用。衣被蛋白对于货物选择和膜变形以从供体区室出芽形成运输囊泡是必需的。人们曾经认为囊泡在识别其靶膜之前必须脱衣。然而，最近的研究结果揭示了衣被在引导囊泡到达其正确的细胞内目的地方面的作用。在这篇综述中，我们将讨论将衣被蛋白与囊泡靶向事件联系起来的文献。
