Panchbhavi Vinod K
Division of Foot & Ankle Surgery, Department of Orthopedic Surgery, University of Texas Medical Branch, 301, University Boulevard, Galveston, TX 77555-0165, USA.
Foot Ankle Clin. 2010 Dec;15(4):559-76. doi: 10.1016/j.fcl.2010.07.004.
Synthetic bone graft materials have an established role as osteoconductive materials. The basic function is providing a matrix to support the attachment of bone-forming cells for subsequent bone formation, but these materials in various forms can be used for other functions. They can be used as a vehicle for local antibiotic delivery and in injectable form they can be used in a minimally invasive fashion to fill voids and strengthen purchase of screws in osteoporotic bones. They can provide prolonged structural support, which is important for early weight bearing in the lower extremity. These are some of the qualities that may not be obtained from autograft bone, the traditional gold standard for bone grafting. Therefore, these synthetic bone graft substitutes have earned a unique place in the armamentarium when issues such as bone defect, bone quality, and bone infection challenge bone healing and repair. This article reviews the basic science and use of such materials in foot and ankle surgery for conditions related to trauma, tumors, and infection.
合成骨移植材料作为骨传导材料已确立了其作用。其基本功能是提供一个基质，以支持成骨细胞的附着，从而促进后续的骨形成，但这些各种形式的材料还可用于其他功能。它们可作为局部抗生素递送的载体，以注射形式可用于微创方式来填充空隙，并增强螺钉在骨质疏松性骨中的固定。它们可提供长期的结构支撑，这对于下肢的早期负重很重要。这些特性有些可能是传统骨移植金标准——自体骨所不具备的。因此，当骨缺损、骨质量和骨感染等问题挑战骨愈合和修复时，这些合成骨移植替代物在治疗手段中赢得了独特地位。本文综述了此类材料的基础科学及其在足踝外科中用于治疗创伤、肿瘤和感染相关病症的应用。
