Azzopardi Thomas, Van Essen Phillipa, Cundy Peter J, Tucker Graeme, Chan Annabelle
Royal Hospital for Sick Children, Glasgow, UK.
J Pediatr Orthop B. 2011 Jan;20(1):1-7. doi: 10.1097/BPB.0b013e3283415927.
A neonatal clinical screening program for developmental dysplasia of the hip (DDH) operates in South Australia to diagnose DDH as early as possible. However, some cases of DDH are diagnosed late (>3 months of age). The aims of this study were to identify the specific risk factors for late diagnosis by comparing early diagnosed DDH, late diagnosed DDH, and normal controls in the South Australian population. There were 1945 children with DDH born between 1988 and 2003, of which 67 cases were late diagnosis (3.4%). Maternal characteristics, pregnancy, and delivery details were analyzed, and compared with controls (early diagnosed DDH and the general population). There was a trimodal pattern of age at presentation with a gradual increase in the incidence of late diagnosed DDH over the time period in this study. Birthweight (<2500 g), birth in a rural setting, and early hospital discharge following delivery (<4 days) were significant risk factors for late diagnosed DDH. Breech presentation and delivery by caesarean section were protective for late diagnosed DDH. Risk factors for late diagnosed DDH relate to factors that influence the screening program. A rigorous population-based hip surveillance program is important for early diagnosis of DDH.
南澳大利亚开展了一项针对发育性髋关节发育不良(DDH)的新生儿临床筛查项目,旨在尽早诊断DDH。然而,部分DDH病例诊断较晚(>3月龄)。本研究的目的是通过比较南澳大利亚人群中早期诊断的DDH、晚期诊断的DDH和正常对照,确定晚期诊断的具体危险因素。1988年至2003年间出生的1945例DDH患儿中,67例为晚期诊断(3.4%)。分析了母亲的特征、妊娠及分娩细节,并与对照组(早期诊断的DDH和普通人群)进行比较。本研究中,就诊年龄呈三峰模式,晚期诊断的DDH发病率随时间逐渐增加。出生体重<2500g、在农村出生以及分娩后早期出院(<4天)是晚期诊断DDH的重要危险因素。臀位分娩和剖宫产对晚期诊断的DDH具有保护作用。晚期诊断DDH的危险因素与影响筛查项目的因素有关。严格的基于人群的髋关节监测项目对于DDH的早期诊断至关重要。