University of Utah (JSB), Salt Lake City, UT, USA.
Pediatr Crit Care Med. 2011 Jul;12(4):387-92. doi: 10.1097/PCC.0b013e3181fe4058.
To provide an updated overview of critical pertussis to the pediatric critical care community and describe a study of critical pertussis recently undertaken.
The six sites, seven hospitals of the Collaborative Pediatric Critical Care Research Network, and 17 outside sites at academic medical centers with pediatric intensive care units.
Despite high coverage for childhood vaccination, pertussis causes substantial morbidity and mortality in US children, especially among infants. In pediatric intensive care units, Bordetella pertussis is a community-acquired pathogen associated with critical illness and death. The incidence of medical and developmental sequelae in critical pertussis survivors remains unknown, and the appropriate strategies for treatment and support remain unclear. The Collaborative Pediatric Critical Care Research Network Critical Pertussis Study has begun to evaluate critical pertussis in a prospective cohort.
Research is urgently needed to provide an evidence base that might optimize management for critical pertussis, a serious, disabling, and too often fatal illness for U.S. children and those in the developing world.
向儿科重症监护界提供有关百日咳重症的最新概述，并描述最近进行的一项百日咳重症研究。
合作儿科重症监护研究网络的六个地点、七个医院和学术医疗中心的 17 个外部地点，设有儿科重症监护病房。
尽管儿童疫苗接种覆盖率很高，但百日咳仍会导致美国儿童出现大量发病率和死亡率，尤其是在婴儿中。在儿科重症监护病房中，百日咳博德特氏菌是一种与重症和死亡相关的社区获得性病原体。重症百日咳幸存者的医疗和发育后遗症的发生率尚不清楚，治疗和支持的适当策略也不清楚。合作儿科重症监护研究网络的重症百日咳研究已开始对重症百日咳进行前瞻性队列研究。
迫切需要开展研究，为重症百日咳的管理提供循证依据，因为这种疾病对美国儿童和发展中国家的儿童来说是一种严重、致残且往往致命的疾病。
