Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Planta Med. 2011 May;77(7):733-5. doi: 10.1055/s-0030-1250526. Epub 2010 Nov 5.
Investigation of the bioactive crude extracts from two populations of the red alga Laurencia dendroidea from the southeastern Brazilian coast led to the identification of five sesquiterpenes: (+)-obtusane (1), a triquinane derivative (2), (-)-elatol (3), obtusol (4), and cartilagineol (5). An antileishmanial bioassay against Leishmania amazonensis was conducted for crude lipophilic extracts and for sesquiterpenes 2, 3, and 4. Compounds 3 and 4 displayed in vitro and in vivo leishmanicidal activity and very low cytotoxicity.
对来自巴西东南海岸的两种红藻枝桠马尾藻的生物活性粗提取物的研究，鉴定出了五个倍半萜：（+）-钝叶烷（1），一个三尖杉烷衍生物（2），（-）-艾拉醇（3），钝叶醇（4）和软骨藻醇（5）。对粗脂溶性提取物以及倍半萜 2、3 和 4 进行了抗利什曼原虫的生物测定。化合物 3 和 4 表现出体外和体内杀利什曼原虫活性和非常低的细胞毒性。
