来自红藻扁枝软骨藻的没药烷类化合物。

Bisabolanes from the red alga Laurencia scoparia.

作者信息

Davyt Danilo, Fernandez Rafael, Suescun Leopoldo, Mombrú Alvaro W, Saldaña Jenny, Domínguez Laura, Fujii Mutue T, Manta Eduardo

机构信息

Facultad de Química, Universidad de la República, Avenida Gral. Flores 2124, Montevideo, Uruguay.

出版信息

J Nat Prod. 2006 Jul;69(7):1113-6. doi: 10.1021/np060235+.

DOI:10.1021/np060235+

PMID:16872159

Abstract

Three novel halogenated beta-bisabolene sesquiterpenoids (1-3), together with two know triquinane alcohol sesquiterpenes (6 and 7), were isolated from the red alga Laurencia scoparia and their structures elucidated by spectroscopic methods. Single-crystal X-ray crystallography allowed us to confirm the structure of 1 as well as to determine the absolute configuration of all stereocenters. To the best of our knowledge, the isolation of beta-bisabolenes from the genus Laurencia has no precedent in the literature. Compound 1 showed weak in vitro anthelmintic activity against parasitant stage (L4) Nippostrongilus brasiliensis.

摘要

从红藻 Laurencia scoparia 中分离出了三种新型卤化β-没药烯倍半萜（1-3），以及两种已知的三环烷醇倍半萜（6 和 7），并通过光谱方法阐明了它们的结构。单晶 X 射线晶体学使我们能够确认 1 的结构，并确定所有立体中心的绝对构型。据我们所知，从 Laurencia 属中分离出β-没药烯在文献中尚无先例。化合物 1 对巴西日圆线虫的寄生阶段（L4）显示出微弱的体外驱虫活性。