钯催化的分子内碳钯化/环化级联反应：多环 N 稠合杂环的构建。
Palladium-catalyzed intramolecular carbopalladation/cyclization cascade: access to polycyclic N-fused heterocycles.
机构信息
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061, USA.
出版信息
Org Lett. 2010 Dec 3;12(23):5558-60. doi: 10.1021/ol102447s. Epub 2010 Nov 8.
Abstract
An efficient palladium-catalyzed intramolecular carbopalladation/cyclization cascade toward tetra- and pentacyclic N-fused heterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with internal propargylic esters or ethers followed by the 5-endo-dig cyclization leading to polycyclic pyrroloheterocycles in moderate to excellent yields.
摘要
发展了一种高效的钯催化的分子内碳钯化/环化级联反应，用于合成四元和五元 N-稠合杂环。该转化通过芳基卤化物与内部炔丙基酯或醚的钯催化偶联，然后进行 5-endo-dig 环化反应，以中等至优异的收率得到多环吡咯杂环。
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