通过串联钯催化的烯烃碳胺化/狄尔斯-阿尔德反应合成多环氮杂环化合物
Synthesis of Polycyclic Nitrogen Heterocycles via Cascade Pd-Catalyzed Alkene Carboamination/Diels-Alder Reactions.
作者信息
White Derick R, Wolfe John P
机构信息
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States.
出版信息
Org Lett. 2015 May 15;17(10):2378-81. doi: 10.1021/acs.orglett.5b00896. Epub 2015 May 6.
Abstract
Cascade Pd-catalyzed alkene carboamination/Diels-Alder reactions between bromodienes and amines bearing two pendant alkenes are described. These transformations generate 4 bonds, 3 rings, and 3-5 stereocenters to afford polycyclic nitrogen heterocycles with high diastereoselectivity.
摘要
描述了级联钯催化的溴代二烯与带有两个侧链烯烃的胺之间的烯烃碳胺化/狄尔斯-阿尔德反应。这些转化反应生成4个键、3个环和3至5个立体中心，以高非对映选择性得到多环氮杂环化合物。
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