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Blind dogs that can see: pharmacological treatment of Leber congenital amaurosis caused by a defective visual cycle.

作者信息

Palczewski Krzysztof

出版信息

Arch Ophthalmol. 2010 Nov;128(11):1483-5. doi: 10.1001/archophthalmol.2010.245.

DOI:10.1001/archophthalmol.2010.245
PMID:21060052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4495581/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753e/4495581/98b0e9c1f143/nihms704187f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753e/4495581/98b0e9c1f143/nihms704187f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753e/4495581/98b0e9c1f143/nihms704187f1.jpg

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本文引用的文献

1
Improvement of visual performance with intravitreal administration of 9-cis-retinal in Rpe65-mutant dogs.玻璃体内注射9-顺式视黄醛对Rpe65突变犬视觉性能的改善
Arch Ophthalmol. 2010 Nov;128(11):1442-8. doi: 10.1001/archophthalmol.2010.210. Epub 2010 Sep 13.
2
Retinoids for treatment of retinal diseases.类视黄醇治疗视网膜疾病。
Trends Pharmacol Sci. 2010 Jun;31(6):284-95. doi: 10.1016/j.tips.2010.03.001.
3
Leber congenital amaurosis due to RPE65 mutations and its treatment with gene therapy.由 RPE65 突变引起的莱伯先天性黑蒙症及其基因治疗。
Prog Retin Eye Res. 2010 Sep;29(5):398-427. doi: 10.1016/j.preteyeres.2010.04.002. Epub 2010 Apr 24.
4
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of vision.视黄醇化学中转式到顺式异构化的生化和结构基础。
Trends Biochem Sci. 2010 Jul;35(7):400-10. doi: 10.1016/j.tibs.2010.01.005. Epub 2010 Feb 24.
5
Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.人工合成的生色团前药9-顺式视黄醇醋酸酯可部分防止因生色团耗竭导致的视锥光感受器丧失。
Hum Mol Genet. 2009 Jun 15;18(12):2277-87. doi: 10.1093/hmg/ddp163. Epub 2009 Apr 1.
6
Leber congenital amaurosis: genes, proteins and disease mechanisms.莱伯先天性黑蒙：基因、蛋白质与疾病机制
Prog Retin Eye Res. 2008 Jul;27(4):391-419. doi: 10.1016/j.preteyeres.2008.05.003. Epub 2008 Jun 1.
7
Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal.膜相关蛋白运输到视锥光感受器外段需要发色团11-顺式视黄醛。
J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008.
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Human cone photoreceptor dependence on RPE65 isomerase.人类视锥光感受器对RPE65异构酶的依赖性。
Proc Natl Acad Sci U S A. 2007 Sep 18;104(38):15123-8. doi: 10.1073/pnas.0706367104. Epub 2007 Sep 11.
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