The Brain Tumor Center, The University of Chicago, Chicago, Illinois, United States of America.
PLoS One. 2010 Oct 23;5(10):e15390. doi: 10.1371/journal.pone.0015390.
Recently, CD4(+)IL-17A(+) T helper 17 (Th17) cells were identified and reported in several diseased states, including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-derived tumors of the central nervous system has not been studied.
METHODOLOGY/PRINCIPAL FINDINGS: In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage markers, IFN-γ and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.
These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further investigation into the role of Th17 cells in malignant glioma.
最近，人们在几种疾病状态中发现并报道了 CD4(+)IL-17A(+)T 辅助 17（Th17）细胞，包括自身免疫、感染和各种外周神经系统肿瘤。然而，中枢神经系统的神经胶质来源肿瘤中是否存在 Th17 细胞尚未得到研究。
方法/主要发现：在本报告中，我们证明了 Th17 细胞细胞因子 IL-17A 的 mRNA 表达以及 Th17 细胞存在于人类脑胶质瘤中。在免疫活性小鼠恶性神经胶质瘤模型中重现了脑胶质瘤中 IL-17A 的 mRNA 表达。此外，在人和小鼠的脑胶质瘤中均证实了 Th17 细胞的存在。有趣的是，在小鼠脑胶质瘤中存在的一些 Th17 细胞分别表达 Th1 和 Th2 谱系标记物 IFN-γ 和 IL-4，但主要表达 Treg 谱系标记物 FoxP3。
这些数据证实了 Th17 细胞存在于神经胶质来源的中枢神经系统肿瘤中，并为进一步研究 Th17 细胞在恶性神经胶质瘤中的作用提供了依据。
