Iljin S V, Shanigina K I, Sydow G, Parfhenova N S
Acta Biol Med Ger. 1977;36(10):1459-62.
The noradrenaline and glycogen contents as well as hexokinase, glucokinase and glucose-6-phosphatase activities were determined in normal, embryonic and partially denervated (bilateral dissection of the Nervus splanchnicus or Nervus vagus) rat liver and in two transplantable hepatomas. In embryonic liver and hepatomas a strong decrease or complete loss of noradrenaline and glycogen levels and glucokinase and glucose-6-phosphatase activities is demonstrable as compared to the livers of adult animals, while the hexokinase activity is enhanced. Following bilateral splanchnicotomy the glycogen content and hexokinase activity are enhanced; the glucose-6-phosphatase activity is reduced, and the liver does not contain any noradrenaline. Bilateral vagotomy causes decrease of the glycogen content, of the hexokinase and glucokinase activities and an enhancement of glucose-6-phosphatase activity. The results lend support to the idea of antagonistic action of the sympathetic and parasympathetic nervous systems upon several partial reactions of carbohydrate metabolism of liver. In addition, it can be assumed that the alterations of the carbohydrate metabolism demonstrable in hepatomas as compared to normal liver are not solely attributable to disturbance or breakdown of the nervous regulation.
测定了正常、胚胎及部分去神经（双侧切断内脏神经或迷走神经）大鼠肝脏以及两种可移植性肝癌中的去甲肾上腺素和糖原含量，以及己糖激酶、葡萄糖激酶和葡萄糖-6-磷酸酶的活性。与成年动物的肝脏相比，在胚胎肝脏和肝癌中，可证明去甲肾上腺素和糖原水平以及葡萄糖激酶和葡萄糖-6-磷酸酶的活性显著降低或完全丧失，而己糖激酶的活性增强。双侧内脏神经切断术后，糖原含量和己糖激酶活性增强；葡萄糖-6-磷酸酶活性降低，肝脏中不含任何去甲肾上腺素。双侧迷走神经切断术导致糖原含量、己糖激酶和葡萄糖激酶活性降低，葡萄糖-6-磷酸酶活性增强。这些结果支持了交感神经系统和副交感神经系统对肝脏碳水化合物代谢的几种部分反应具有拮抗作用的观点。此外，可以假定，与正常肝脏相比，肝癌中可证明的碳水化合物代谢改变并非仅仅归因于神经调节的紊乱或破坏。
