Department of Ophthalmology, Chosun University College of Medicine, Gwangju, Korea.
J Korean Med Sci. 2010 Nov;25(11):1688-91. doi: 10.3346/jkms.2010.25.11.1688. Epub 2010 Oct 26.
Two schizophrenic patients who had been taking medication for a long period presented with visual disturbance of 6-month duration. Slit-lamp examination revealed fine, discrete, and brownish deposits on the posterior cornea. In addition, bilateral star-shaped anterior subcapsular lens opacities, which were dense, dust-like granular deposits, were noted. Although we strongly suspected that the patient might have taken one of the drugs of the phenothiazine family, we were unable to obtain a history of medications other than haloperidol and risperidone, which were taken for 3 yr. We performed a drug profiling test using urine samples and detected methotrimeprazine. The patient underwent surgery for anterior subcapsular lens opacities. Visual acuity improved in both eyes, but the corneal deposits remained. We report an unusual case of methotrimeprazine-induced corneal deposits and cataract in a patient with psychosis, identified by using the urine drug profiling test.
两位长期服药的精神分裂症患者出现了 6 个月的视觉障碍。裂隙灯检查显示后角膜上有细小、离散、呈棕色的沉积物。此外，还发现双侧星状前囊下晶状体混浊，呈密集的尘状颗粒状沉积物。尽管我们强烈怀疑患者可能服用了吩噻嗪类药物中的一种，但除了已经服用 3 年的氟哌啶醇和利培酮之外，我们无法获得其他药物的用药史。我们使用尿液样本进行了药物分析测试，检测到了甲氧噻嗪。患者接受了前囊下晶状体混浊的手术。双眼视力均有所提高，但角膜沉积物仍存在。我们报告了一例使用尿液药物分析测试确定的精神患者甲氧噻嗪诱导的角膜沉积物和白内障的不常见病例。
