Thaler J S, Curinga R, Kiracofe G
Am J Optom Physiol Opt. 1985 Sep;62(9):600-4. doi: 10.1097/00006324-198509000-00004.
The fact that larger doses of phenothiazine medications cause more anterior chamber (lens and cornea) pigmentation in schizophrenics has been apparent since the introduction of these neuroleptic drugs nearly 30 years ago. The present study relates the extent of pigmentation to the dose and duration of phenothiazine administration in long-term schizophrenics. An investigation and analysis of the medication records of 272 pigmented schizophrenics show a statistically significant correlation between most of the pigmentation grades and the associated dose of medication. The results indicate that regular biomicroscopy examinations for pigmentation can help confirm medication history and classify schizophrenics.
自从近30年前引入这些抗精神病药物以来，大剂量的吩噻嗪类药物会在精神分裂症患者中导致更多的前房（晶状体和角膜）色素沉着这一事实就已很明显。本研究将色素沉着程度与长期精神分裂症患者服用吩噻嗪的剂量和时长联系起来。对272名有色素沉着的精神分裂症患者的用药记录进行调查和分析后发现，大多数色素沉着等级与相关药物剂量之间存在统计学上的显著相关性。结果表明，定期进行色素沉着的生物显微镜检查有助于确认用药史并对精神分裂症患者进行分类。
