Abaid Lisa N, Mosquera-Caro Monica, Kankus Rita C, Goldstein Bram H
Gynecologic Oncology Associates, Hoag Cancer Center, Newport Beach, Calif., USA.
Case Rep Oncol. 2010 Sep 9;3(3):310-314. doi: 10.1159/000320740.
Granulosa cell tumors are rare sex cord stromal lesions that comprise approximately 3% of all ovarian neoplasms. The vast majority of granulosa cell tumors are considered indolent but in spite of aggressive management, delayed recurrence is of significant concern. CASE REPORT: We describe a case involving a 67-year-old woman who presented with abdominal pain, bloody stools, and mild nausea. Following a CT scan of the abdomen and pelvis, a 19-cm pelvic mass was identified. Her prior medical history included a hysterectomy for uterine fibroids 40 years ago and a bilateral salpingo-oophorectomy for a presumed granulosa cell tumor 20 years ago. Final pathology revealed granulosa cell tumor with small bowel mesentery involvement. The patient underwent surgical resection and adjuvant chemotherapy; she is currently doing well. CONCLUSION: Granulosa cell tumors are considered to be of low malignant potential but they have the capacity to recur, even several years following initial patient management. This case exemplifies the disease's capacity for prolonged recurrence and further accentuates the significance of long-term follow-up in these patients.
颗粒细胞瘤是罕见的性索间质病变，约占所有卵巢肿瘤的3%。绝大多数颗粒细胞瘤被认为生长缓慢，但尽管采取了积极的治疗措施，延迟复发仍是一个重大问题。病例报告：我们描述了一例67岁女性患者，她出现腹痛、便血和轻度恶心症状。腹部和盆腔CT扫描后，发现一个19厘米的盆腔肿块。她既往病史包括40年前因子宫肌瘤行子宫切除术，20年前因疑似颗粒细胞瘤行双侧输卵管卵巢切除术。最终病理显示为累及小肠系膜的颗粒细胞瘤。患者接受了手术切除和辅助化疗；她目前情况良好。结论：颗粒细胞瘤被认为具有低恶性潜能，但它们有复发的可能，即使在最初治疗数年之后。本病例例证了该疾病长期复发的可能性，并进一步强调了对这些患者进行长期随访的重要性。
