菟丝子种子中的两种新木脂苷。

Two new lignan glycosides from the seeds of Cuscuta chinensis.

作者信息

He Xiang-Hui, Yang Wen-Zhi, Meng A-Hui, He Wen-Ni, Guo De-An, Ye Min

机构信息

The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, China.

出版信息

J Asian Nat Prod Res. 2010 Nov;12(11):934-9. doi: 10.1080/10286020.2010.506434.

DOI:10.1080/10286020.2010.506434

PMID:21061214

Abstract

Two new lignan glycosides, 2'-hydroxyl asarinin 2'-O-β-D-glucopyranoside (cuscutoside C, 1) and 2'-hydroxyl asarinin 2'-O-β-D-apiofuranosyl-(1 → 2)-[β-D-glucopyranosyl-(1 → 6)]-β-D-glucopyranoside (cuscutoside D, 2), were isolated from the seeds of Cuscuta chinensis Lam., along with six known compounds, 2'-hydroxyl asarinin 2'-O-β-D-glucopyranosyl-(1 → 6)-β-D-glucopyranoside (3), 2'-hydroxyl asarinin 2'-O-β-D-apiofuranosyl-(1 → 2)-β-D-glucopyranoside (cuscutoside A, 4), kaempferol 3,7-di-O-β-D-glucopyranoside (5), 5-caffeoyl quinic acid (6), 4-caffeoyl quinic acid (7), and cinnamic acid (8). Their structures were elucidated on the basis of spectroscopic analyses including HR-ESI-MS, ESI-MS/MS, (1)H and (13)C NMR, HSQC, HMBC, and TOCSY.

摘要

从中国菟丝子种子中分离得到两个新的木脂素糖苷，2'-羟基细辛脂素2'-O-β-D-吡喃葡萄糖苷（菟丝子苷C，1）和2'-羟基细辛脂素2'-O-β-D-阿糖呋喃糖基-(1→2)-[β-D-吡喃葡萄糖基-(1→6)]-β-D-吡喃葡萄糖苷（菟丝子苷D，2），以及六个已知化合物，2'-羟基细辛脂素2'-O-β-D-吡喃葡萄糖基-(1→6)-β-D-吡喃葡萄糖苷（3）、2'-羟基细辛脂素2'-O-β-D-阿糖呋喃糖基-(1→2)-β-D-吡喃葡萄糖苷（菟丝子苷A，4）、山奈酚3,7-二-O-β-D-吡喃葡萄糖苷（5）、5-咖啡酰奎宁酸（6）、4-咖啡酰奎宁酸（7）和肉桂酸（8）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、电喷雾串联质谱（ESI-MS/MS）、氢核磁共振（1H NMR）、碳核磁共振（13C NMR）、异核单量子相干谱（HSQC）、异核多键相关谱（HMBC）和全相关谱（TOCSY）等光谱分析对它们的结构进行了鉴定。