转化生长因子β降低大鼠胰岛异种移植物（大鼠到小鼠）的免疫原性，并与用抗干扰素γ单克隆抗体治疗受体相结合预防排斥反应。
Transforming growth factor beta decreases the immunogenicity of rat islet xenografts (rat to mouse) and prevents rejection in association with treatment of the recipient with a monoclonal antibody to interferon gamma.
作者信息
Carel J C, Schreiber R D, Falqui L, Lacy P E
机构信息
Department of Pathology, Washington University School of Medicine, Saint Louis, MO 63110.
出版信息
Proc Natl Acad Sci U S A. 1990 Feb;87(4):1591-5. doi: 10.1073/pnas.87.4.1591.
Culture of rat islets of Langerhans for 1 week at 37 degrees C with recombinant transforming growth factor beta prolonged the survival of islet xenografts transplanted into diabetic mouse recipients. Treatment of diabetic recipients with a neutralizing monoclonal antibody to murine interferon gamma did not affect the survival of islet xenografts cultured 7 days in control medium. However, treatment of donor islets with transforming growth factor beta in combination with treatment of diabetic recipients with interferon gamma antibody produced a 75% survival of the islet xenografts at 100 days. Fifty percent of the recipients who had accepted their graft for more than 100 days were immune unresponsive to a transplant of freshly isolated islets from the same donor strain.
将大鼠胰岛在37摄氏度下用重组转化生长因子β培养1周，可延长移植到糖尿病小鼠受体中的胰岛异种移植物的存活时间。用抗小鼠干扰素γ的中和单克隆抗体治疗糖尿病受体，对在对照培养基中培养7天的胰岛异种移植物的存活没有影响。然而，用转化生长因子β处理供体胰岛并结合用干扰素γ抗体治疗糖尿病受体，在100天时胰岛异种移植物的存活率达到75%。接受移植物超过100天的受体中，有50%对来自同一供体品系的新鲜分离胰岛移植无免疫反应。
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