Kuzina I N, Kilikovskiĭ V V, Smirnova O V
Fiziol Cheloveka. 2010 Sep-Oct;36(5):101-9.
We studied concentrations of cortisol, its precursors and active form in human blood and relation to the changes in concentration of central and peripheral hormonal regulators (total 36 parameters) in healthy male volunteers aged 18-72 y.o. The study demonstrated a significant decrease in blood concentrations of unutilazed cortisol precursors (pregnenolone and progesterone) with advanced age accompanied by maintenance of total and free cortisol concentrations. We found age-related decrease in ACTH level that is a known hypophysial stimulant of cortisol and cortisol precursor synthesis in adrenal glands. Cortisol and ACTH levels in study population had different correlation behavior in relation to central and peripheral regulators for hormonal axes.
cortisol level remains stable with advanced age in males despite the decrease in steroidogenic activity and blood ACTH level. This may be due to the imbalance in the regulation of cortisol and ACTH production by central and peripheral regulators especially by hormones of reproductive and somatotrophic axes.
我们研究了18 - 72岁健康男性志愿者血液中皮质醇及其前体和活性形式的浓度，以及它们与中枢和外周激素调节因子浓度变化（共36项参数）的关系。研究表明，随着年龄增长，未利用的皮质醇前体（孕烯醇酮和孕酮）的血液浓度显著降低，而总皮质醇和游离皮质醇浓度保持不变。我们发现促肾上腺皮质激素（ACTH）水平随年龄下降，ACTH是已知的肾上腺皮质醇和皮质醇前体合成的垂体刺激物。研究人群中皮质醇和ACTH水平与激素轴的中枢和外周调节因子的相关性表现不同。
尽管类固醇生成活性和血液ACTH水平下降，但男性随着年龄增长皮质醇水平仍保持稳定。这可能是由于中枢和外周调节因子，特别是生殖和生长激素轴的激素对皮质醇和ACTH产生的调节失衡所致。
