McGivern R F, Sokol R Z, Adey W R
Harbor-UCLA Medical Center, Torrance.
Teratology. 1990 Jan;41(1):1-8. doi: 10.1002/tera.1420410102.
Pregnant Sprague-Dawley dams were exposed to a low-level, low-frequency pulsed electromagnetic (EM) field (15 Hz, 0.3 msec duration, peak intensity 8 gauss) for 15 min twice a day from day 15 through day 20 of gestation, a period in development that is critical for sexual differentiation of the male rat brain. No differences in litter size, number of stillborns, or body weight were observed in offspring from field-exposed dams. At 120 days of age, field-exposed male offspring exhibited significantly less scent marking behavior than controls. Accessory sex organ weights, including epididymis, seminal vesicles, and prostate, were significantly higher in field-exposed subjects at this age. However, circulating levels of testosterone, luteinizing hormone, and follicle-stimulating hormone, as well as epididymal sperm counts, were normal. These data indicate that brief, intermittent exposure to low-frequency EM fields during the critical prenatal period for neurobehavioral sex differentiation can demasculinize male scent marking behavior and increase accessory sex organ weights in adulthood.
怀孕的斯普拉格-道利母鼠在妊娠第15天至第20天期间，每天两次暴露于低水平、低频脉冲电磁场（15赫兹，持续时间0.3毫秒，峰值强度8高斯），每次15分钟，这一发育时期对雄性大鼠大脑的性别分化至关重要。在暴露于电磁场的母鼠所生的后代中，未观察到窝仔数、死产数或体重有差异。在120日龄时，暴露于电磁场的雄性后代表现出的气味标记行为明显少于对照组。此时，暴露于电磁场的实验对象的附属生殖器官重量，包括附睾、精囊和前列腺，明显更高。然而，睾酮、促黄体生成素和促卵泡激素的循环水平以及附睾精子计数均正常。这些数据表明，在神经行为性别分化的关键产前时期，短暂、间歇性暴露于低频电磁场会使成年雄性的气味标记行为雄性化程度降低，并增加附属生殖器官的重量。
